Pros:

• The city is a regional hub within Latin America
• Fantastic quality of life
• Cheap flights to different South American cities
• Vibrant nightlife and dining out scene
• Wide range of accommodation options
• Subway system
• Santiago offers a range of easily accessible outdoor activities
• Picturesque city with a backdrop of the Andes Mountains
• No corruption in the police force
• Stable government and safe country to relocate to
• Large and diverse expat community
• Tasty and inexpensive seafood and quality local wines
• Relatively low crime rate compared with other large Latin American cities

Cons:

• Language barrier - some Spanish is vital.
• City tends to close on weekends as everyone goes to the beach/mountains/family
• Long work weeks
• Smoking indoors is still common
• Road signs are not bilingual
• More expensive than most Latin American countries
• Earthquakes